Elevated plasma α-defensins in patients with acute exacerbation of fibrotic interstitial pneumonia
نویسندگان
چکیده
منابع مشابه
Association of elevated α-defensin levels with interstitial pneumonia in patients with systemic sclerosis
BACKGROUND Interstitial lung disease (ILD) is the leading cause of mortality in patients with systemic sclerosis (SSc). Although the pathogenesis of SSc-ILD is not well understood, neutrophils may play a pivotal role in this process. Neutrophils store azurophil granules that contain defensins, antimicrobial peptides that function in regulating the inflammatory response, and IL-8, a potent chemo...
متن کاملA cohort study of mortality predictors in patients with acute exacerbation of chronic fibrosing interstitial pneumonia
OBJECTIVES To assess clinical, laboratory and radiographic findings associated with outcomes and to clarify more practical ways to predict hospital mortality in patients with acute exacerbation (AE) of chronic fibrosing interstitial pneumonia (CFIP). DESIGN Single-centre retrospective cohort study. SETTING University Hospital in Japan. PARTICIPANTS We identified 51 consecutive patients wi...
متن کاملStatin-induced fibrotic nonspecific interstitial pneumonia.
Statins inhibit the 3-hydroxy-3-methylglutaryl coenzyme A reductase, reduce the serum level of low-density lipoprotein cholesterol, and are extensively prescribed to prevent cardiovascular mortality and morbidity. Few systemic adverse effects, such as pseudopolymyositis, lupus-like syndromes, and anecdotal hypersensitivity pneumonitis, have been reported. A simvastatin-induced diffuse interstit...
متن کاملComparing Serum Procalcitonin Levels Between Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Patients with Acute Exacerbation of Asthma
Background and purpose: Serum procalcitonin (PCT) indicates a bacterial infection that can reduce the administration of antibiotics. The aim of this study was to compare serum procalcitonin levels in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and asthma and its relationship with lung function and inflammatory factors. Materials and methods: In this cross-s...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2015
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2014.12.015